Publications
2019
Yasi E., Eisen A., Wang H., Sugianto W., Minniefield A., Hoover K., Branham P., Peralta-Yahya P. Rapid deorphanization of human olfactory receptors, Biochemistry, 10.1021/acs.biochem.8b01208.
2018
Sarria S., Bartholow T., Verga A., Burkart M., Peralta-Yahya P. Matching protein interfaces for improved medium-chain fatty acid production, ACS Synth Biol, 7, 1179-1187, 2018.
2017
Sarria S., Kruyer N., Peralta-Yahya P. Microbial synthesis of medium-chain chemicals form renewables, Nat Biotechnol, 35, 1158-1166, 2017.
Ehrenworth A.M., Claiborne T., Peralta-Yahya P. Medium-throughput screen of microbially produced serotonin via a GPCR-based sensor, Biochemistry, 56, 5471-5475, 2017.
Ehrenworth A., Haines M., Wong A., Peralta-Yahya P. Quantifying the efficiency of Saccharomyces cerevisiae translocation tags,
Biotechnol Bioeng, 114, 2628-2636, 2017.
Kruyer N., Peralta-Yahya P. Metabolic engineering strategies to bio-adipic acid production, Curr Opin Biotechnol, 45, 136-143, 2017.
Ehrenworth A., Peralta-Yahya P. Accelerating the semi-synthesis of alkaloid-based drugs through metabolic engineering. Nat Chem Biol, 13, 249-258, 2017.
In the news: GaTech COS, Phys.org, Health medicinet
2015
Ehrenworth A., Sarria S., Peralta-Yahya P. Pterin-dependent mono-oxidation for the microbial synthesis of a modified monoterpene indole alkaloid ACS Synth Biol, 4, 1295-1307, 2015.
In the news: Petit Institute News
Ort DR, Merchant SS, Alric, Blankenship RE, Bock R, Croce R, Hanson MR, Hibberd JM, Long SP, Moore TA, Moroney J, Niyogi KK, Parry MA,
Peralta-Yahya P., Prince RC, Redding KE, Spalding MH, van Wijk KJ, Vermaas WF, von Caemmerer S, Weber AP, Yeates TO, Yuan JS, Zhu XG.
Redesigning photosynthesis to sustainably meet global food and bioenergy demand, Proc. Natl Acad Sci USA, 112, 8529-36, 2015.
In the news: Gizmodo
Mukherjee K., Bhattacharyya S., Peralta-Yahya, P. GPCR-based chemical sensors for medium-chain fatty acids, ACS Synth Biol, 4, 1261-9, 2015.
In the news: Petit Institute News
Peralta-Yahya P. Biosensor keep DOPA on track, News & Views, Nat Chem Biol, 11, 450-1, 2015.
In the news: PBS NewsHour, Science Magazine, Science News
2014
Sarria S., Wong B., Garía Martín H., Keasling J., Peralta-Yahya P. Microbial synthesis of pinene, ACS Synth Biol, 3, 466-75, 2014.
In the news: Science Daily, Popular Science, Scientific American, Chemical and Engineering News
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Yasi E., Eisen A., Wang H., Sugianto W., Minniefield A., Hoover K., Branham P., Peralta-Yahya P. Rapid deorphanization of human olfactory receptors, Biochemistry, 10.1021/acs.biochem.8b01208.
2018
Sarria S., Bartholow T., Verga A., Burkart M., Peralta-Yahya P. Matching protein interfaces for improved medium-chain fatty acid production, ACS Synth Biol, 7, 1179-1187, 2018.
2017
Sarria S., Kruyer N., Peralta-Yahya P. Microbial synthesis of medium-chain chemicals form renewables, Nat Biotechnol, 35, 1158-1166, 2017.
Ehrenworth A.M., Claiborne T., Peralta-Yahya P. Medium-throughput screen of microbially produced serotonin via a GPCR-based sensor, Biochemistry, 56, 5471-5475, 2017.
Ehrenworth A., Haines M., Wong A., Peralta-Yahya P. Quantifying the efficiency of Saccharomyces cerevisiae translocation tags,
Biotechnol Bioeng, 114, 2628-2636, 2017.
Kruyer N., Peralta-Yahya P. Metabolic engineering strategies to bio-adipic acid production, Curr Opin Biotechnol, 45, 136-143, 2017.
Ehrenworth A., Peralta-Yahya P. Accelerating the semi-synthesis of alkaloid-based drugs through metabolic engineering. Nat Chem Biol, 13, 249-258, 2017.
In the news: GaTech COS, Phys.org, Health medicinet
2015
Ehrenworth A., Sarria S., Peralta-Yahya P. Pterin-dependent mono-oxidation for the microbial synthesis of a modified monoterpene indole alkaloid ACS Synth Biol, 4, 1295-1307, 2015.
In the news: Petit Institute News
Ort DR, Merchant SS, Alric, Blankenship RE, Bock R, Croce R, Hanson MR, Hibberd JM, Long SP, Moore TA, Moroney J, Niyogi KK, Parry MA,
Peralta-Yahya P., Prince RC, Redding KE, Spalding MH, van Wijk KJ, Vermaas WF, von Caemmerer S, Weber AP, Yeates TO, Yuan JS, Zhu XG.
Redesigning photosynthesis to sustainably meet global food and bioenergy demand, Proc. Natl Acad Sci USA, 112, 8529-36, 2015.
In the news: Gizmodo
Mukherjee K., Bhattacharyya S., Peralta-Yahya, P. GPCR-based chemical sensors for medium-chain fatty acids, ACS Synth Biol, 4, 1261-9, 2015.
In the news: Petit Institute News
Peralta-Yahya P. Biosensor keep DOPA on track, News & Views, Nat Chem Biol, 11, 450-1, 2015.
In the news: PBS NewsHour, Science Magazine, Science News
2014
Sarria S., Wong B., Garía Martín H., Keasling J., Peralta-Yahya P. Microbial synthesis of pinene, ACS Synth Biol, 3, 466-75, 2014.
In the news: Science Daily, Popular Science, Scientific American, Chemical and Engineering News
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Graduate and Postdoctoral work
2013
de Rond T., Peralta-Yahya P., Cheng X., Northen T.R., Keasling J.D. Versatile synthesis of probes for high-throughput enzyme activity screening, Anal Bioanal Chem, 405, 4969-73, 2013.
2012
Romanini D., Peralta-Yahya P., Mondol V., Cornish V.W. A heritable recombination system for synthetic darwinian evolution in yeast, ACS Synth Biol, 1, 602-9, 2012.
Peralta-Yahya P., Zhang F., del Cardayre S.B., Keasling J.D. Microbial engineering for the production of advanced biofuels, Nature, 488, 320-28, 2012.
2011
McAndrew R,P., Peralta-Yahya P., DeGiovanni A., Pereira J.H., Hadi M.Z., Keesling J.D., Adams P.D. Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production. Structure, 19, 1875-84, 2011.
Peralta-Yahya P., Ouellet M., Chan R., Mukhopadhyay A., Keasling J.D., Lee T.S. Identification and microbial production of a terpene-based advanced biofuel, Nat Commun 2:483, doi: 10.1038/ncomms1494, 2011.
Bokinsky G., Peralta-Yahya P., George A., Holmes B.M., Steen E.J., Dietrich J., Lee T.S., Tullman-Ercek D., Voigt C.A., Simmons B.A., Keasling J.D Synthesis of three advanced biofuels from ionic liquid-pretreated switchgrass using engineered Escherichia coli, Proc Natl Acad Sci USA. 108, 19949-54, 2011.
2010
Pirakitikulr N., Ostrov N., Peralta-Yahya P., Cornish, V.W. PCRless library mutagenesis via oligonucleotide recombination in yeast. Protein Sci, 19, 2336-46, 2010.
Peralta-Yahya P., Keasling J.D. Advanced biofuel production in microbes, Biotechnol J, 5, 147-62, 2010.
2008
Peralta-Yahya P., Carter B.T., Lin H., Tao H., Cornish V.W. High-throughput selection for cellulase catalysts using chemical complementation, J Am Chem Soc, 130, 17446-52, 2008.
Tao H., Peralta-Yahya P., Decatur J., Cornish V.W. Characterization of a new glycosynthase cloned by using chemical complementation, ChemBioChem, 9, 681-4, 2008.
2006
H. Tao, P. Peralta-Yahya, H. Lin, V.W. Cornish., Optimized design and synthesis of chemical dimerizer substrates for detection of glycosynthase activity via chemical complementation, Bioorg Med Chem, 14, 6940-53, 2006.
2013
de Rond T., Peralta-Yahya P., Cheng X., Northen T.R., Keasling J.D. Versatile synthesis of probes for high-throughput enzyme activity screening, Anal Bioanal Chem, 405, 4969-73, 2013.
2012
Romanini D., Peralta-Yahya P., Mondol V., Cornish V.W. A heritable recombination system for synthetic darwinian evolution in yeast, ACS Synth Biol, 1, 602-9, 2012.
Peralta-Yahya P., Zhang F., del Cardayre S.B., Keasling J.D. Microbial engineering for the production of advanced biofuels, Nature, 488, 320-28, 2012.
2011
McAndrew R,P., Peralta-Yahya P., DeGiovanni A., Pereira J.H., Hadi M.Z., Keesling J.D., Adams P.D. Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production. Structure, 19, 1875-84, 2011.
Peralta-Yahya P., Ouellet M., Chan R., Mukhopadhyay A., Keasling J.D., Lee T.S. Identification and microbial production of a terpene-based advanced biofuel, Nat Commun 2:483, doi: 10.1038/ncomms1494, 2011.
Bokinsky G., Peralta-Yahya P., George A., Holmes B.M., Steen E.J., Dietrich J., Lee T.S., Tullman-Ercek D., Voigt C.A., Simmons B.A., Keasling J.D Synthesis of three advanced biofuels from ionic liquid-pretreated switchgrass using engineered Escherichia coli, Proc Natl Acad Sci USA. 108, 19949-54, 2011.
2010
Pirakitikulr N., Ostrov N., Peralta-Yahya P., Cornish, V.W. PCRless library mutagenesis via oligonucleotide recombination in yeast. Protein Sci, 19, 2336-46, 2010.
Peralta-Yahya P., Keasling J.D. Advanced biofuel production in microbes, Biotechnol J, 5, 147-62, 2010.
2008
Peralta-Yahya P., Carter B.T., Lin H., Tao H., Cornish V.W. High-throughput selection for cellulase catalysts using chemical complementation, J Am Chem Soc, 130, 17446-52, 2008.
Tao H., Peralta-Yahya P., Decatur J., Cornish V.W. Characterization of a new glycosynthase cloned by using chemical complementation, ChemBioChem, 9, 681-4, 2008.
2006
H. Tao, P. Peralta-Yahya, H. Lin, V.W. Cornish., Optimized design and synthesis of chemical dimerizer substrates for detection of glycosynthase activity via chemical complementation, Bioorg Med Chem, 14, 6940-53, 2006.